|Khaled ALASAAD ALWEKYAN||Benjamin LEVY||Amad KAYTOUE||Amine HALIMI|
School / University
Vincent FLACHER, PhD
3D models of cutaneous sensory and perception innervation
Latest research shows an important increase of dermal diseases, especially atopic dermatitis, which has affected these last years more than a third of all children and more than 10% of adults. Verneuil disease, another dermal disease affects more than 1% of the population, enduring painful symptoms and inflammation.
Research models have been proposed by research laboratories, using skin grafts based on stem cells. The most important missing part in these models is the innervation of the different components of the skin, and the sebaceous glands which are very difficult to reproduce in vitro.
The primary purpose of our innovative idea consists in developing cutaneous sensory and perception innervation which play a major role in skin physiopathology inflammation with sebaceous glands based on stem cells matrix and by using biomaterials to maintain the efficiency and durability of the grafts by finding the perfect consistency and biocompatibility, which will allow us to test other substances, caracterise and propose treatments for diseases such as those mentioned before, as well as contribute to rapid wound closure.
.Poster / Images
Diagram Organo-Skin composition (longitudinal section view from above)